Maybe we are already familiar with breadfruit. If you love to consumption breadfruit, there's good news. Apparently, plants that grow around us has powerful properties for health, especially for the heart disease and blood vessels disorder.Heart disease and blood vessel disease is increasingly a big health problem along with lifestyle changes. Diet high in animal fat or lack of physical activity and smoking habits into several risk factors trigger the heart and blood vessel disorders.
All parts of the breadfruit plants containing flavonoids. A number of flavone derivatives have been isolated and identified the roots and twigs of this plant before. Breadfruit (Artocarpus altilis) is included in Moraceae family or Mulberry family.
Plants are grown in tropical regions, like Indonesia, Thailand, Vietnam, and Myanmar. Indonesian people use the leaves of breadfruit for the traditionally treatment of liver disease, inflammation, heart, kidney, tooth pain, and itching.
Taiwanese society has used the roots and stems for the traditionally treatment of heart disease and hypertension. How to use the breadfruit for treatment is to boil the leaves, though nutritious, but still less useful to know the specific content of large, how to use, and dose.
Through long research since 2004, breadfruit plants successfully proved his usefulness. In that study, breadfruit leaves are made into extracts. Extraction with ethanol yield components, namely the three flavonoids and beta-sitoserol which is then examined usefulness.
Efficacy study of breadfruit leaves include platelet aggregation (clumping thrombocyte), blood viscosity and acute ischemia (lack of blood flow to the heart). The study also includes atherosclerosis (thickening of the walls of blood vessels due to fat accumulation), which includes the accumulation of lipids (fats) in the aorta, and blood cholesterol.
Efficacy tests in vitro (in an artificial environment) and in vivo (in live bodies) against the plant extract showed very good results.
Studies in vivo, for example, concluded that the ethyl acetate extract containing flavonoids and beta-sitoserol with a ratio of 100 mg / kg and 20 mg / kg inhibits platelet aggression, reduces blood viscosity, and protect it protects the heart from acute ischemia.
Next, test the efficacy of ethyl acetate extract on blood cholesterol levels and accumulation of fat in the blood vessel wall of the aorta in Wistar rats showed that the ethyl acetate extract dose of 150 mg / kg body weight can reduce blood cholesterol levels significantly.
Breadfruit is also able to inhibit fat accumulation in the aortic blood vessel walls. "There was no accumulation of fat," says Tjandrawati.
Power poison
In that study also tested the power breadfruit leaf extract poison from them. The good news, subkronis toxicity tests conducted during 90 days in the rat strain Sprague Dawley conclude that administration of ethyl acetate extract of leaves of breadfruit with varying doses, ie, the test dose of 83.33 mg / kg body weight per day, 166.65 mg / kg bodies per day, and 333.35 mg / kg body weight per day did not affect the function of the heart, kidneys, liver or blood profile.
Acute toxicity test in male and female ICR mice using high doses of total flavonoids 4.5 g / kg body weight and Beta-sitoserol 2.5 g / kg body weight showed no weight loss and even tended to rise. Observations on the behavior of test animals during the experiment, such as how to test animals to walk, eat, drink, and the brightness of the eyes and hair and also did not show signs of poisoning.
